Journal of Clinical Case Reports Medical Images and Health Sciences

  Multidrug Resistance Pattern of Klebsiella Isolates from Clinical Samples in a Tertiary Health Facility in Southeast Nigeria by Bridget O. Amechi in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract The development of multi-drug resistant (MDR)  Klebsiella  is a global public health issue with mortality rates among patients infected with MDR  Klebsiella  as high as 64.0%. This study aimed to investigate the prevalence of infection and multidrug resistance pattern of  Klebsiella  isolates in Federal Medical Centre Umuahia (FMCU). We examined the MDR pattern of  Klebsiella  isolates, and explored the association between  Klebsiella  spp and clinical specimen in FMCU. Eighty-four (84) isolates were obtained from 2,510 clinical specimens between January 2022 and June 2022 in FMCU and identified using standard microbiological procedure and biochemical panel tests. Isolates were subjected to antimicrobial ac...

  Effect of conditioning activities of upper and lower limbs on the performance of the throttle drop by Jefferson de Souza Epifanio in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract Introduction : Post-activation potentiation (PPA) is a physiological phenomenon capable of increasing muscle performance during high-intensity physical exercises. The objective of the present study was to evaluate the central and local mechanisms of potentialization of physical performance through conditioning activities of upper and lower limbs, seeking in this way to know which mechanism of potentialization of physical performance brings more significant results and if the flexion exercises of arm and jumps against movements presents significant values to trigger potentiation. Methodology : The sample consisted of 20 volunteers, 13 male volunteers and 7 female volunteers, practitioners of physical activities for a minimum period of 6 months, aged between 18 and 35 years,...

  Adverse Drug Reactions Awareness Among Sample of People in Northern Region, Saudi Arabia by Fawwaz Freih Alshammarie in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract Background: Drug reactions are a fundamental issue in many branches of medicine. Adverse drug reactions result in high mortality and morbidity globally. There is always the risk of unwanted side effects associated with the use of any substance that has a therapeutic effect. The safe use of drugs remains a critical issue for all health care professionals. Objective: The current study investigates the level of drug reaction awareness among the public in northern Saudi Arabia. Materials/methods: This was a questionnaire-based cross-sectional study. Data were collected using Google Forms, which were coded and processed using Microsoft Excel and SPSS version 23. Results: Altogether 475 people participated in this study including 382 women (80.4%) and 93 men (19.6%). Of the 475 participants,...

  Aetiologies and outcomes of Abdomino-Pelvic surgical Mergencies at iten county referral Hospital, Kenya by Shazim Harunani in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract Background - Abdomino-pelvic surgical emergencies represents more than half of all emergency surgical admissions. Acute  appendicitis tops the list in most published series as  the leading aetiology of abdomino-pelvic surgical emergencies followed by intestinal obstruction. Abdomino-pelvic surgical emergencies are associated with a high mortality estimated at 5% to 25%. This study is meant to describe common aetiologies and the mortality rate associated with abdomino-pelvic emergencies at iten county referral hospital(ICRH). Methodology- This study was a retrospective descriptive study, carried out at the ICRH  , Elgeyo marakwet county, Kenya and  included patients who were operated due to abdomino-pelvic surgical emergencies at the ICRH between January 15th ...

  Low-dose Methotrexate in the treatment of knee Osteoarthritis. Case report by Ergys Ramosaço in Journal of Clinical Case Reports Medical Images and Health Sciences Abstract Osteoarthritis (OA) is a degenerative disease, that affects all joints, but the knee joint is most often affected. Pain is the most disturbing sign for patients that forces them to seek medical care. There are in place many treatment strategies for knee osteoarthritis. The knee osteoarthritis treatment plan should be personalized for each patient. We present a patient, who has been diagnosed with knee OA. We use low-dose methotrexate in the treatment of knee osteoarthritis. After six months, the patient has an improvement in pain with 4 points (from 10 to 6). This case demonstrated that the use of methotrexate in knee osteoarthritis provided a clinically relevant reduction in knee pain and improvement in physical function Keywords:  Osteoarthritis, pain, treatment, methotrexate Introduction Osteoarthri...

  Genetic basis to an extraordinary response to Vinorelbine chemotherapy in metastatic triple negative breast cancer by Dr Lawrence Panasci in Journal of Clinical Case Reports Medical Images and Health Sciences Case report Patients with metastatic triple negative breast cancer have a short median survival (17 months) (1). In these patients, first line chemotherapy results in less than 5% complete remissions while second or third line chemotherapy almost never results in sustained complete remission. Two important classes of anticancer drugs utilized to treat metastatic breast cancer are: (a) vinca alkaloids such as vinorelbine and (b) taxanes such as paclitaxel (2). While these agents are effective, resistance develops quickly and patients with triple negative metastatic breast cancer have a median survival of less than 24 months after starting chemotherapy (1). The mechanism of action of the vinca alkaloids involves binding to tubulin heterodimers eventually causing dissolution ...